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histone deacetylase

Classification: - 3 classes of histone deacetylases: a) class 1: homologous to yeast Rpd3 includes HDAC-1,2,3,8 b) class 2: homologous to yeast Hda1 includes HDAC-4,5,6,7,9 c) class 3: homologous to yeast & mouse Sir2 includes SIRT-1,2,3,4,5,6,7 Function: - gives a tag for epigenetic repression - plays a role in transcriptional regulation, cell cycle progression & developmental events - histone deacetylases act via the formation of large multiprotein complexes - primarily involved in transcription repression through compaction of chromatin by removal of acetyl groups from Lys & exposing positive charge ...Lys-NH-Ac -> ...Lys-NH3+ - histone deacetylases have targets other than histones, including p53, E2F, GATA1, TFIIE & TFIIF Inhibition: - inhibited by trichostatin A (TSA), butyrate, trapoxin

Related

histone deacetylase (HDAC) core complex

Specific

histone deacetylase 1 (reduced potassium dependency 3 [RPD3] homolog-like 1, HDAC1, RPD3L1) histone deacetylase 10 (HDAC10) histone deacetylase 11 (HDAC11, HD11) histone deacetylase 2 (HDAC2) histone deacetylase 3 (HDAC3, HD3, RPD3-2, SMAP45) histone deacetylase 4 (HDAC4) histone deacetylase 5 (HD5, antigen NY-CO-9, HDAC5 KIAA0600) histone deacetylase 6 (HDAC6) histone deacetylase 7A (HDAC7A) histone deacetylase 8 (HDAC8, CDA07, HDACL1) histone deacetylase 9 (HD9, HD7B, HD7, histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HDAC9, HDAC7, HDAC7B,, HDRP KIAA0744, MITR) silent information regulator 2 (Sir2) protein sirtuin (silent mating type information regulation 2 homolog)

General

amidohydrolase

Figures/Diagrams

RB/E2F1 interactions

Properties

MOTIF: active site

References

  1. Marks P et al Histone deacetylases and cancer: causes and therapies. Nature Reviews Cancer 1:194-202, 2001 PMID: 11902574
  2. Gray SG, Ekstrom TJ. The human histone deacetylase family. Exp Cell Res. 2001 Jan 15;262(2):75-83. Review. PMID: 11139331

Components

histone deacetylase complex subunit SAP30L (Sin3A-associated protein p30-like protein, Sin3 corepressor complex subunit SAP30L, HCV non-structural protein 4A-transactivated protein 2, SAP30L, NS4ATP2)