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host cell factor 2 (HCF-2, C2 factor, HCFC2)
Function:
1) binds MLL
2) detected in a histone methyltransferase complex containing MLL, ASH2L, WDR5, RBBP5 & MEN1
Structure:
- contains 3 fibronectin F3 modules
- contains 4 Kelch repeats
Compartment: cytoplasm, nucleus
Expression:
- highly expressed in testis
- detected at lower levels in spleen, thymus, prostate, ovary, small intestine, colon
General
protein subunit
Properties
SIZE: MW = 87 kD
entity length = 792 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: kelch repeat {34-79}
kelch repeat {83-130}
kelch repeat {207-255}
kelch repeat {257-303}
fibronectin type III domain or F3 module {357-442}
fibronectin type III domain or F3 module {580-672}
fibronectin type III domain or F3 module {678-782}
Database Correlations
OMIM 607926
UniProt Q9Y5Z7
PFAM correlations
References
UniProt :accession Q9Y5Z7
Component-of
MLL complex