host cell factor C1 regulator 1 (HCF-1 beta-propeller-interacting protein, HCFC1R1, HPIP)

Function: - regulates HCFC1 activity by modulating its subcellular localization - overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm - HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus - interacts with HCFC1 Compartment: - cytoplasm, nucleus - shuttles between the nucleus & cytoplasm (CRM1-dependent) Alternative splicing: named isoforms=2 Expression: widely expressed

Properties

GENERAL: uncharacterized protein SIZE: entity length = 138 aa MW = 15 kD COMPARTMENT: cytoplasm cell nucleus FORM: host cell factor C1 regulator 1 MOTIF: HCFC1 interaction {76-79} nuclear export signal {110-119}

References

UniProt :accession Q9NWW0