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hyaluronan synthase 2; hyaluronate synthase 2; hyaluronic acid synthase 2; HA synthase 2 (HAS2)
Function:
- role in hyaluronan/hyaluronic acid synthesis
- glycan biosynthesis; hyaluronan biosynthesis
Cofactor: Mg+2
Structure: belongs to the nodC/HAS family
Compartment: membrane (probable)
Expression: expressed in fibroblasts
Pathology:
- chromosomal aberration involving HAS2 with PLAG1 (q12.1 to 8q24.1 intrachromosomal rearrangement) may be a cause of lipoblastomas
General
hyaluronan synthase (hyaluronic acid synthase, HA synthase)
Properties
SIZE: entity length = 552 aa
MW = 64 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-11}
transmembrane domain {12-32}
exoplasmic loop {33-45}
transmembrane domain {46-66}
cytoplasmic loop {67-374}
transmembrane domain {375-395}
exoplasmic loop {396-402}
transmembrane domain {403-423}
cytoplasmic loop {424-429}
transmembrane domain {430-450}
exoplasmic loop {451-475}
transmembrane domain {476-496}
cytoplasmic loop {497-510}
transmembrane domain {511-531}
exoplasmic domain {532-552}
Database Correlations
OMIM 601636
UniProt Q92819
Pfam PF03142
Entrez Gene 3037
Kegg hsa:3037
ENZYME 2.4.1.212
References
- UniProt :accession Q92819
- GGDB; glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/