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haptoglobin in serum
Indications:
- evaluation of anemia
- hemolytic anemia
- evaluation of hemolysis
Reference values:
- Adult: 13-163 mg/dL
- 15-150 mg/dL [6]
Clinical significance:
- haptoglobin in an acute phase reactant, thus increased in inflammatory disorders
- haptoglobin binds to free oxy-hemoglobin, thus levels are diminished by hemolysis
Decreases:
- hemolytic disease
- hepatocellular disease
- megaloblastic anemia
- hemolytic transfusion reaction
- malaria
- congenital defects that influence erythrocyte stability:
- sickle-cell disease & other hemoglobinopathies
- glucose-6-phosphate dehydrogenase deficiency
- hereditary spherocytosis
- thalassemia & related disorders
Increases:
- bacterial infection
- viral infection
- burns
- tumors associated with necrosis & inflammation
- myocardial infarction
Related
haptoglobin; contains: haptoglobin alpha chain; haptoglobin beta chain (HP)
nephelometry
Specific
haptoglobin in serum by electrophoresis
haptoglobin in serum by nephlometry
General
haptoglobin in body fluid
References
- Beckman Array Protein System Operating Manual.
- Teitz, Norbert W.: Textbook of Clinical Chemistry, W. B.
Saunders, Co, Philadelphia, PA, pp. 592-594, 1986.
- Bauer, John D., Ackerman, Phillip G., Toro, Gelson: Clinical
Laboratory Methods, The C.V. Mosby Co., St. Louis, MO, 8th
Edition; pp. 140-141.
- MedlinePlus: Haptoglobin
http://www.nlm.nih.gov/medlineplus/ency/article/003634.htm
- Haptoglobin
Laboratory Test Directory ARUP: 50280
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
Component-of
anemia panel
hemolysis panel