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heart & neural crest derivatives-expressed protein 2 (deciduum, heart, autonomic nervous system & neural crest derivatives-expressed protein 2; dHAND; HAND2)
Function:
1) cardiac morphogenesis, especially formation of right ventricle & of aortic arch arteries
2) vascular development & regulation of angiogenesis, viA VEGF signaling (putative)
3) role in limb development, especially anterior-posterior polarization
4) upstream regulator of sonic hedgehog induction in the limb bud
5) development of branchial arches
6) binds DNA on E-box consensus sequence 5'-CANNTG-3'
- efficient DNA binding requires dimerization with another bHLH protein
- homodimers & heterodimers with TCF3 gene products E12 & E47, HAND1 & HEY1, HEY2 & HEYL
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
Expression: heart, fetal heart
General
other protein
Properties
SIZE: MW = 24 kD
entity length = 217 aa
MOTIF: alanine-rich region {21-32}
MOTIF: alanine residue (SEVERAL)
DNA-binding motif
SITE: 99-111
helix-loop-helix
NAME: helix-loop-helix
SITE: 112-155
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 602407
UniProt P61296
Pfam PF00010
References
UniProt :accession P61296