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halofantrine (Halfan)
Indications:
- alternative agent for treatment of chloroquine-resistant malaria
* potential to be repurposed as COVID-19 therapy [3]
Contraindications: pregnancy
Dosage:
1) 8 mg/kg repeated at 6 & 12 hours
2) may be repeated in 1 week in patients without immunity
Adverse effects:
1) abdominal pain
2) diarrhea
3) pruritus
4) dose-related prolongation of PR & QTc
Drug interactions:
- other agents that prolong the QT interval
1) quinine
2) quinidine
3) mefloquine
Interactions
drug interactions
drug adverse effects of antimalarials
Related
malaria
General
antimalarial
Database Correlations
PUBCHEM correlations
References
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1174
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- The Scripps Research Institute
Extensive study identifies over a dozen existing drugs as potential
COVID-19 therapies.
MedicalXpress 2021. June 3
https://medicalxpress.com/news/2021-06-extensive-dozen-drugs-potential-covid-.html