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hallucinogen; psychodysleptic
Clinical manifestations:
- alteration in perception, thought, or mood
- despite the name, most hallucinogens do not consistently cause hallucinations
Complications:
- persons with emergency department visit following hallucinogen use have a 21-fold higher risk of developing schizophrenia vs general population [4]
Notes:
- hallucinogen chemistry may help guide antidepressant drug discovery [3]
Interactions
drug interactions
drug adverse effects of psychotropic agents
Specific
phencyclidine; phenylcyclohexyl piperidine (Sernylan, PCP, angel dust)
psilocin; psilotsin; 4-hydroxy N,N-dimethyltryptamine
psilocybin; indocybin (magic mushroom)
Salvia divinorum (Sally D, magic mint)
salvinorin A
salvinorin B
General
psychotropic agent
References
- Sinert RO
Fast Five Quiz: Psilocybin and Other Hallucinogenic Drugs.
Medscape. September 07, 2021
https://reference.medscape.com/viewarticle/957547
- Forrest JS, Xiong GL
Hallucinogen Use
Medscape. September 28, 2020
https://emedicine.medscape.com/article/293752-overview#showall
- Halford B
Hallucinogen chemistry guides antidepressant drug discovery.
Chemical & Engineering News. Jan 27, 2022
https://cen.acs.org/pharmaceuticals/drug-discovery/Hallucinogen-chemistry-guides-antidepressant-drug/100/web/2022/01
- Cao D, Yu J, Wang H et al
Structure-based discovery of nonhallucinogenic psychedelic analogs.
Science 2022. 375(6579):403-411. Jan 27
PMID: 35084960
https://www.science.org/doi/10.1126/science.abl8615
- Myran DT, Pugliese M, Xiao J et al
Emergency Department Visits Involving Hallucinogen Use and Risk of Schizophrenia
Spectrum Disorder.
JAMA Psychiatry. 2024 Nov 13.
PMID: 39535804
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2825649