intracellular hyaluronan-binding protein 4 (IHABP4, Ki-1/57 intracellular antigen, HABP4)

Function: - role in nuclear functions including remodeling of chromatin & regulation of transcription (putative) - interacts with C-terminus of CHD3 - interacts via its C-terminal region with GNB2L1, interaction abolished by phosphorylation - interacts with TP53/p53 - able to bind hyaluronan; however, its intracellular localization suggests that this interaction may not be relevant in vivo - phosphorylation by phorbol 12-myristate 13-acetate (PMA)- activated PKC isoforms at Thr-354 & Thr-375 (probable) results in exit of HABP4 from the nucleus Compartment: - cytoplasm, nucleus - ransported into nuclear compartment in activated leukocytes Alternative splicing: named isoforms=2 Expression: - expressed in brain, heart & kidney > skeletal muscle - expression in activated but not resting leukocytes Pathology: - expressed in a variety of tumor cell lines

General

hyaluronan-binding protein phosphoprotein

Properties

SIZE: MW = 46 kD entity length = 413 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {40-64} Thr phosphorylation site {T354} Thr phosphorylation site {T375}

Database Correlations

UniProt Q5JVS0 Pfam PF04774

References

UniProt :accession Q5JVS0