hormone replacement after breast cancer diagnosis-is it safe? (HABITS) trial

Two scandanavian randomized control studies: Studies termininated in Dec of 2003 Design: 434 women, survivors of breast cancer with menopausal symptoms 1) 219 randomized to receive hormone-replacement therapy (HRT) 2) 215 controls, without HRT Results: 1) 26 women in HRT group experienced new breast cancer events vs 8 in control group (relative risk 3.3) 2) serious adverse events more common in HRT group (8 vs 4)

References

- Journal Watch 24(6):47-48, 2004 - Holmberg L et al HABITS (hormonal replacement therapy after breast cancer- is it safe?), a randomised comparison: trial stopped. Lancet 363:453, 2004 PMID: 14962527 - Chlebowski RT & Col N Menopausal hormone therapy after breast cancer. Lancet 363:410, 2004 PMID: 14962515