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Helicobacter pylori (H pylori) stool/tissue antigen assay

Indications: - H pylori infection - follow-up to evaluate success of H pylori treatment [4] - iron-deficiency anemia resistant to oral iron [4] Principle: - immunoassay for detecting H pylori antigen in feces Sensitivity: 94% Specificity: 86% Clinical significance: - useful for assessing eradication of H pylori 4 weeks post treatment Sensitivity: 90% Specificity: 95% - false negatives may occur with: a) recent gastrointestinal bleeding b) use of proton pump inhibitor* of H2 antagonists* c) antibiotics or bismuth-containing compounds Notes: - consider H pylori serology in patients on therapy with proton pump inhibitor or H2 blocker or with recent gastrointestinal bleeding Meridien Diagnostics, Inc Cincinnati OH

General

Helicobacter pylori antigen

References

  1. UpToDate 2004 http://www.uptodate.com
  2. Liston R et al, Lancet 347:269, 1996
  3. Helicobacter pylori Ag, Fecal by EIA Laboratory Test Directory ARUP: 65147
  4. Medical Knowledge Self Assessment Program (MKSAP) 16, 17 American College of Physicians, Philadelphia 2012, 2015