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histone-H3
Function:
1) core component of nucleosome
2) H3 Lys-9 methylation is a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones
3) methylated on Lys-9 by SETDB2
4) H3 tails trimethylated on Lys-4 (H3K4Me3)
a) mark transcription start sites of virtually all active genes
b) recognized by BPTF (FALZ), component of the NuRF complex
Specific
histone H3-like (H3F3C)
histone H3.1; H3/a; H3/b; H3/c; H3/d; H3/f; H3/h; H3/i; H3/j; H3/k; H3/l (HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, HIST1H3F, H3FI, HIST1H3G, H3FH, HIST1H3H, H3FK, HIST1H3I, H3FF, HIST1H3J, H3FJ)
histone H3.1t; histone-H3.4; H3 histone family, member t; H3t; H3/t; H3/g (HIST3H3, H3FT)
histone H3.3; histone-H3.B; H3 histone, family 3B (H3.3B, H3F3A, H33A, H3F3, PP781, H3F3B, H33B)
histone H3.X; histone H3.Y2 (H3Y2)
histone H3.Y; histone H3.Y1 (H3Y1)
histone HIST2H3PS2 (H3-2, HIST2H3PS2)
histone-H3.2 (H3/m, H3/o, HIST2H3A)
General
histone
Properties
COMPARTMENT: cell nucleus
Database Correlations
OMIM 142780
References
- UniProt :accession Q96T68
- UniProt :accession Q12830
Component-of
nucleosome