histone-H2A

Function: 1) core component of nucleosome 2) the nucleosome is a histone octamer containing 2 molecules each of H2A, H2B, H3 & H4 assembled in one H3-H4 heterotetramer & 2 H2A-H2B heterodimers 3) chromatin-associated form is phosphorylated on Thr-120 during mitosis 4) monoubiquitination of Lys gives a specific tag for epigenetic transcriptional repression in different histone H2A proteins 5) ubiquitinated H2A is enriched in inactive X chromosome chromatin 6) ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3

Specific

core histone macro-H2A.1; histone macroH2A1; medulloblastoma antigen MU-MB-50.205 (H2AFY, MACROH2A1, mH2A1, H2A.y, H2A/y) core histone macro-H2A.2 (Histone macroH2A2, mH2A2) (H2AFY2 MACROH2A2) histone H2A 1-H (HIST1H2AH, HIST1H2AI) histone H2A type 1-A (HIST1H2AA) histone H2A type 1-B/E; histone-H2A.5; H2A/m; H2A.2; H2A/a (HIST1H2AB, H2AFM, HIST1H2AE, H2AFA, H2A.5) histone H2A type 1-C (HIST1H2AC, H2AFL) histone H2A type 1-D; H2A.3 (HIST1H2AD, H2AFG) histone H2A type 1-J; histone-H2A.E; H2A/e (HIST1H2AJ, H2AFE, H2AJ) histone H2A type 1; H2A.1; histone-H2A.4, H2A/p (HIST1H2AG, H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2AM, H2AFN) histone H2A type 2-A; H2A.2; H2A/o (HIST2H2AA3, H2AFO, HIST2H2AA, HIST2H2AA4) histone H2A type 2-B (HIST2H2AB) histone H2A type 2-C (H2A-GL101, H2A/r, HIST2H2AC, H2AFQ) histone H2A type 3 (HIST3H2A) Histone H2A-Bbd type 1 (H2A Barr body-deficient, H2A.Bbd, H2AFB1) Histone H2A-Bbd type 2/3 (H2A Barr body-deficient, H2A.Bbd, H2AFB2, H2ABBD, H2AFB) histone H2A.J; H2a/j (H2AFJ) histone H2A.x; H2a/x (H2AFX, H2AX) histone H2A.Z; H2A/z (H2AFZ, H2AZ) histone H2AV (H2A.F/Z, H2AFV, H2AV)

Properties

COMPARTMENT: cell nucleus MOTIF: binding site FOR-BINDING-OF: ubiquitin