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H2 receptor antagonist
Adverse effects:
- some associated with delirium in the elderly [1]
- strongest evidence associating cimetidine with delirium in the elderly [1]
- increased risk of hip fracture [2]
- no increase in risk [3]
- use during the 1st 6 months of life associated with increased risk for food allergy during childhood (RR=2.2) [4]
Interactions
drug interactions
drug adverse effects of H2-receptor antagonists
Specific
cimetidine (Tagamet, Cimetex)
famotidine (Pepcid, Apogastine)
methscopolamine (Pamine)
nizatidine (Axid)
ranitidine (Zantac, Gastrosedol)
General
histamine receptor antagonist (antihistamine)
References
- Prescriber's Letter 19(7): 2012
H2-Blockers in the Elderly
Detail-Document#: 280703
(subscription needed) http://www.prescribersletter.com
- Corley DA, Kubo A, Zhao W, Quesenberry C.
Proton pump inhibitors and histamine-2 receptor antagonists
are associated with hip fractures among at-risk patients.
Gastroenterology 2010; 139(1):93-101. Epub 2010 Mar 27.
PMID: 20353792
- Eom CS, Park SM, Myung SK, Yun JM, Ahn JS.
Use of acid-suppressive drugs and risk of fracture:
a meta-analysis of observational studies.
Ann Fam Med. 2011 May-Jun;9(3):257-67. doi: 10.1370/afm.1243.
PMID: 21555754
- Mitre E, Susi A, Kropp LE, et al
Association Between Use of Acid-Suppressive Medications and
Antibiotics During Infancy and Allergic Diseases in Early
Childhood.
JAMA Pediatr. Published online April 2, 2018
PMID: 29610864
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2676167