Search
histone-H1
Function:
- histone H1 binds to 'linker DNA' (~ 80 base-pairs) between nucleosomes, helping stabilize the 30 nm chromatin fiber [1,2]
- it binds DNA at the sites of entry to & exit from the nucleosome, sealing off the nucleosome (illustration in [1,3])
Interactions
molecular events
Specific
histone H1.0; histone H1(0); histone H1' (H1F0 H1FV)
histone H1.1; histone H1a; H1 histone family, member 1 (HIST1H1A, H1F1)
histone H1.2; histone H1d; H1 histone family, member 2 (HIST1H1C, H1F2)
histone H1.3; histone H1c; H1 histone family, member 3 (HIST1H1D, H1F3)
histone H1.4; histone H1b; histone H1e; H1 histone family, member 4 (H1F4)
histone H1.5; histone H1b; H1 histone family, member 5 (HIST1H1B, H1F5)
histone H1oo (oocyte-specific histone H1, oocyte-specific linker histone H1, osH1, H1FOO, H1OO, OSH1)
histone H1t; testicular H1 histone; H1 histone family, member T (HIST1H1T, H1FT, H1T)
histone H1x; histone family, member X (H1FX)
spermatid-specific linker histone H1-like protein (HILS1)
testis-specific H1 histone (haploid germ cell-specific nuclear protein 1, histone H1t2, H1FNT, HANP1)
General
histone
phosphoprotein
Properties
COMPARTMENT: cell nucleus
MOTIF: S/T phosphorylation site
Database Correlations
OMIM 142709
References
- Wikipedia: Histone H1
http://en.wikipedia.org/wiki/Histone_H1
- Widom J
Chromatin structure: Linking structure to function with histone H1
Current Biology 1998, 8:R788-R791
http://biomednet.com/elecref/09609822008R0788
http://www.biochem.northwestern.edu/widomweb/pdfpapers/Chromatin%20Structure_1.pdf
- Lamar D
HISTONE H1 GenBank Search
http://www.bio.davidson.edu/courses/Molbio/MolStudents/spring2000/lamar/histoneh1.htm
Component-of
molecular complex