GTP-binding protein Rit1 (Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1, RIT1, RIBB, RIT, ROC1)

Function: - role in coupling NGF stimulation to activation of both EPHB2 & MAPK14 signaling pathways & in NGF-dependent neuronal differentiation - stimulation of the NGF & EGF receptor signaling pathways results in rapid & prolonged activation - alternate between an inactive form bound to GDP & an active form bound to GTP - rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members - interacts with MLLT4, the C-terminal domain of RALGDS & RLF, but not with RIN1 & PIK3CA - RLF binds exclusively to the active GTP-bound form - strongly interacts with BRAF, but only weakly with RAF1 - BARF & RAF1 association is dependent upon the GTP-bound state Structure: belongs to the small GTPase superfamily, Ras family Compartment: cell membrane Expression: expressed in many tissues

Properties

SIZE: MW = 25 kD entity length = 219 aa COMPARTMENT: plasma membrane CELL: unspecified cell type ORGANISM: mammal MOTIF: GTP-binding site SITE: 28-35 GTP-binding site SITE: 75-79 GTP-binding site SITE: 134-137

Database Correlations

UniProt Q92963 Pfam PF00071

References

UniProt :accession Q92963