GTP-binding protein GEM; GTP-binding mitogen-induced T-cell protein; RAS-like protein KIR (GEM, KIR)

Function: - could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane - has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity - phosphorylated on Tyr - interacts with calmodulin in a Ca⁺²-dependent manner - binds ROCK1 Structure: belongs to the small GTPase superfamily, RGK family Compartment: - cell membrane - peripheral membrane protein, cytoplasmic side Expression: - most abundant in thymus, spleen, kidney, lung, & testis - less abundant in heart, brain, liver & skeletal muscle - induced by mitogens

Properties

SIZE: entity length = 296 aa MW = 34 kD COMPARTMENT: cytoplasm MOTIF: GTP-binding site SITE: 82-89 GTP-binding site SITE: 191-194 binding site SITE: 266-285 FOR-BINDING-OF: calmodulin

Database Correlations

OMIM 600164 UniProt P55040 Pfam PF00071 Entrez Gene 2669 Kegg hsa:2669

References

UniProt :accession P55040