GTP-binding protein ARD1; ADP-ribosylation factor domain-containing protein 1; tripartite motif-containing protein 23; RING finger protein 46 (TRIM23, ARD1, ARFD1, RNF46)

Function: - not known - the C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit - interacts with PSCD1 Structure: - in the C-terminal section; belongs to the small GTPase superfamily, Arf family - contains 1 B box-type Zn⁺² finger - contains 1 RING-type Zn⁺² finger Compartment: - endomembrane system, Golgi membrane, lysosome membrane - membrane-associated with the Golgi complex & lysosomal structures Alternative splicing: named isoforms=3; alpha, beta, gamma

General

guanine nucleotide regulatory protein (GNRP) tripartite motif-containing protein (trim protein)

Properties

SIZE: entity length = 574 aa MW = 64 kD COMPARTMENT: lysosome golgi MOTIF: RING-finger {31-76} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif zinc finger B box SITE: 122-168 EFFECTOR-BOUND: Zn+2 coiled coil {346-383} ARF-like {390-574} MOTIF: GTP-binding site SITE: 411-418 GTP-binding site SITE: 454-458 coiled coil {482-502} GTP-binding site SITE: 513-516

Database Correlations

OMIM 601747 UniProt P36406 PFAM correlations Entrez Gene 373 Kegg hsa:373

References

prosite :accession PS01019