general transcription factor 3C polypeptide 4; transcription factor IIIC-delta subunit; TF3C-delta; TFIIIC 90 kD subunit; TFIIIC90 (GTF3C4)

Function: - essential for RNA polymerase 3 to make a number of small nuclear RNAs & cytoplasmic RNAs, both cellular & viral origin including: 5S RNA, tRNA, & adenovirus-associated (VA) RNA - has histone acetyltransferase activity (HAT) with unique specificity for free & nucleosomal H3 - may cooperate with GTF3C5 in facilitating the recruitment of TFIIIB & RNA polymerase through direct interactions with BRF1, POLR3C & POLR3F - may be localized close to the A box - part of the TFIIIC subcomplex TFIIIC2 - interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C & POLR3F acetyl-CoA + histone CoA + acetylhistone Structure: belongs to the TFIIIC subunit 4 family Compartment: nucleus

General

acetyltransferase phosphoprotein protein subunit

Properties

SIZE: entity length = 822 aa MW = 92 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S611}

Database Correlations

OMIM 604892 UniProt Q9UKN8 ENZYME 2.3.1.48

References

UniProt :accession Q9UKN8