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general transcription factor IIF subunit 2; ATP-dependent helicase GTF2F2; general transcription factor IIF 30 kD subunit; transcription initiation factor IIF subunit beta; TFIIF-beta; transcription initiation factor RAP30 (GTF2F2, RAP30)
Function:
- small subunit of TFIIF
- RNA Polymerase 2 recruitment activity resides in small subunit of TFIIF
- has ATP-dependent DNA-helicase activity
- interacts with HTATSF1 & GPBP1 (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: belongs to the TFIIF beta subunit family
Compartment: nucleus
General
helicase (DNA unwinding protein, DNA untwisting protein)
phosphoprotein
transcription factor IIF subunit
Properties
SIZE: entity length = 249 aa
MW = 28 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
ATP-binding site
NAME: ATP-binding site
SITE: 36-43
Ser phosphorylation site {S142}
Ser phosphorylation site {S248}
Database Correlations
OMIM 189969
UniProt P13984
Pfam PF02270
Entrez Gene 2963
Kegg hsa:2963
ENZYME 3.6.4.12
References
- Joliot V, Demma M, Prywes R.
Interaction with RAP74 subunit of TFIIF is required for
transcriptional activation by serum response factor.
Nature. 1995 Feb 16;373(6515):632-5.
PMID: 7854423
- UniProt :accession P13984
Component-of
transcription factor IIF (TFIIS)