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glutathione S-transferase zeta 1; maleylacetoacetate isomerase (GSTZ1)
Function:
- bifunctional enzyme
- minimal glutathione-conjugating activity with ethacrynic acid & 7-chloro-4-nitrobenz-2-oxa-1,3-diazole
- maleylacetoacetate isomerase (MAAI) activity
- low glutathione peroxidase activity with T-butyl & cumene hydroperoxides
- able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid
- amino-acid degradation; L-phenylalanine degradation
- acetoacetate & fumarate from L-phenylalanine: step 5/6
4-maleylacetoacetate 4-fumarylacetoacetate
RX + glutathione HX + R-S-glutathione
Cofactor: glutathione, required for the MAAI activity
Structure:
- homodimer
- belongs to the GST superfamily, Zeta family
Compartment: cytoplasm (putative)
Expression:
- expressed in liver > kidney, skeletal muscle & brain
- also expressed in melanocytes, synovium, placenta, breast & fetal liver & heart
Polymorphism:
- SNPs in intron 1 of GSTZ1 are associated in longevity [2]
General
glutathione transferase
Properties
SIZE: entity length = 216 aa
MW = 24 kD
COMPARTMENT: cytoplasm
MOTIF: serine residue {S14}
Database Correlations
OMIM 603758
UniProt O43708
PFAM correlations
Entrez Gene 2954
Kegg hsa:2954
ENZYME 5.2.1.2
References
- UniProt :accession O43708
- Di Cianni F et al
MAP3K7 and GSTZ1 are associated with human longevity:
a two-stage case-control study using a multilocus genotyping.
Age (Dordr). 2012 May 11
PMID: 22576335