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glycogen synthase kinase 3 (GSK3)
Function:
- hierarchical phosphorylation (see recognition motif, (@ is acidic residue)
- phosphorylates & inactivates factor involved in eIF-2 GDP/GTP-exchange activity
- GSK-3 is inactivated in response to insulin
Interactions
molecular events
Specific
glycogen synthase kinase 3-alpha (GSK3A)
glycogen synthase kinase 3-beta (GSK3B)
General
proline-directed protein kinase
Figures/Diagrams
Wnt1 signalling pathway
Properties
STATE: active state
MOTIF: S/T phosphorylation site
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
MISC-INFO: RECOGNITION-MOTIF
:SEQUENCE X[S*]XXX@X
X[S*]XXX[S-PHOS]X
:REF " - Kemp BE, Pearson RB.
Protein kinase recognition sequence motifs.
Trends Biochem Sci. 1990 Sep;15(9):342-6. Review.
PMID: 2238044"