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growth hormone-releasing hormone; somatotropin-releasing hormone,; somatocrinin; somatoliberin (GHRH)
Function:
- induces growth hormone release from pitituary somatotrophs
- synergistic with endogenous GHRP in stimulating GH release from the pituitary
Compartment:
- secreted
- released from the hypothalamus into the portal circulation
Expression:
- may be secreted in a pulsatile manner &/or in alternation with somatostatin, giving rise to the pulsatile secretion of growth hormone from the anterior pituitary
Pharmacology: see recombinant growth hormone-releasing hormone
Related
appetite-regulating hormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide; M46 protein; contains: ghrelin-27, ghrelin-28, ghrelin, obestatin (GHRL, MTLRP, UNQ524/PRO1066)
growth hormone-releasing hormone receptor; GHRH receptor; GRF receptor; GRFR (GHRHR)
insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)
somatotropin; growth hormone; somatropin (GH)
Specific
recombinant growth hormone-releasing hormone
sermorelin (Geref)
General
pituitary hormone-releasing hormone; hypothalamic hormone
secretin family peptide
Properties
COMPARTMENT: extracellular compartment
Database Correlations
OMIM 139190
UniProt P01286
Pfam PF00123
Entrez Gene 2691
Kegg hsa:2691
References
- UniProt :accession P01286
- Wikipedia, Growth hormone releasing hormone
http://en.wikipedia.org/wiki/GHRH