Metabotropic glutamate receptor 8; mGluR8 (GRM8, GPRC1H, MGLUR8)

Function: - receptor for glutamate - activity is mediated by a Gi-protein - interacts with PICK1 (putative) Structure: belongs to the G-protein coupled receptor 3 family Compartment: cell membrane Alternative splicing: named isoforms=3; mGluR8a, mGluR8b, mGluR8c

General

glycoprotein metabotropic glutamate receptor

Properties

SIZE: entity length = 908 aa MW = 102 kD COMPARTMENT: post synaptic membrane CELL-REGION: dendrite CELL: neuron MOTIF: signal sequence {1-33} exoplasmic domain {34-583} MOTIF: N-glycosylation site {N95} N-glycosylation site {N298} N-glycosylation site {N452} N-glycosylation site {N480} N-glycosylation site {N565} transmembrane domain {584-608} cytoplasmic loop {609-620} transmembrane domain {621-641} exoplasmic loop {642-647} transmembrane domain {648-668} cytoplasmic loop {669-695} transmembrane domain {696-716} exoplasmic loop {717-746} transmembrane domain {747-768} cytoplasmic loop {769-781} transmembrane domain {782-803} exoplasmic loop {804-818} transmembrane domain {819-843} cytoplasmic domain {844-908}

Database Correlations

OMIM 601116 UniProt O00222 PFAM correlations Kegg hsa:2918

References

UniProt :accession O00222