Metabotropic glutamate receptor 7; mGluR7 (GRM7, GPRC1G, MGLUR7)

Function: - receptor for glutamate - activity is mediated by a Gi-protein - interacts with PICK1 (putative) Structure: belongs to the G-protein coupled receptor 3 family Compartment: cell membrane Alternative splicing: named isoforms=5 Expression: - expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, & cerebellum - expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 & isoform 4

General

glycoprotein metabotropic glutamate receptor phosphoprotein

Properties

SIZE: entity length = 915 aa MW = 102 kD COMPARTMENT: post synaptic membrane CELL-REGION: dendrite CELL: neuron MOTIF: signal sequence {1-34} exoplasmic domain {35-590} MOTIF: N-glycosylation site {N98} N-glycosylation site {N458} N-glycosylation site {N486} N-glycosylation site {N572} transmembrane domain {591-615} cytoplasmic loop {616-627} transmembrane domain {628-648} exoplasmic loop {649-654} transmembrane domain {655-675} cytoplasmic loop {676-702} transmembrane domain {703-723} exoplasmic loop {724-753} transmembrane domain {754-775} cytoplasmic loop {776-788} transmembrane domain {789-810} exoplasmic loop {811-825} transmembrane domain {826-850} cytoplasmic domain {851-915} MOTIF: Ser phosphorylation site {S900}

Database Correlations

OMIM 604101 UniProt Q14831 PFAM correlations Entrez Gene 2917 Kegg hsa:2917

References

UniProt :accession Q14831