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Metabotropic glutamate receptor 4; mGluR4 (GRM4, GPRC1D, MGLUR4)
Function:
- receptor for glutamate
- activity is mediated by a Gi-protein
- interacts with PICK1 (putative)
Structure: belongs to the G-protein coupled receptor 3 family
Compartment: cell membrane
Expression:
- strongly expressed in the cerebellum
- expressed at low levels in hippocampus, hypothalamus & thalamus
- no expression detected in liver
General
glycoprotein
metabotropic glutamate receptor
Properties
SIZE: entity length = 912 aa
MW = 102 kD
COMPARTMENT: post synaptic membrane
CELL-REGION: dendrite
CELL: neuron
MOTIF: signal sequence {1-32}
exoplasmic domain {33-587}
MOTIF: N-glycosylation site {N98}
N-glycosylation site {N301}
N-glycosylation site {N454}
N-glycosylation site {N484}
N-glycosylation site {N569}
transmembrane domain {588-610}
cytoplasmic loop {611-624}
transmembrane domain {625-645}
exoplasmic loop {646-656}
transmembrane domain {657-675}
cytoplasmic loop {676-699}
transmembrane domain {700-720}
exoplasmic loop {721-750}
transmembrane domain {751-772}
cytoplasmic loop {773-785}
transmembrane domain {786-808}
exoplasmic loop {809-821}
transmembrane domain {822-847}
cytoplasmic domain {848-912}
Database Correlations
OMIM 604100
UniProt Q14833
PFAM correlations
Entrez Gene 2914
Kegg hsa:2914
References
UniProt :accession Q14833