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glutamate receptor epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; hNR3; NR3 (GRIN2B, NMDAR2B)

Function: - NMDA receptor subunit - high Ca+2 permeability - voltage-dependent sensitivity to Mg+2 - mediated by glycine - forms heteromeric channel of: a) zeta subunit (GRIN1) b) epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) c) 3rd subunit (GRIN3A or GRIN3B) - found in a complex with GRIN1 & GRIN3B - found in a complex with GRIN1, GRIN3A & PPP2CB - interacts with PDZ domains of INADL & DLG4 (putative) - interacts with MAGI3 - phosphorylation by PKC enhances activity (putative) Structure: - belongs to the glutamate-gated ion channel (TC 1.A.10) family Compartment: - cell membrane - cell junction, synapse, postsynaptic cell membrane Expression: - mRNA expressed only in forebrain - primarily found in the fronto-parieto-temporal cortex & hippocampus pyramidal cells - lower expression in the basal ganglia

Interactions

molecular events

General

glutamate receptor epsilon or glutamate receptor, ionotropic NMDA 2 (GRIN2) glycoprotein phosphoprotein

Properties

SIZE: entity length = 1484 aa MW = 166 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-557} MOTIF: signal sequence {1-26} N-glycosylation site {N74} N-glycosylation site {N341} N-glycosylation site {N348} N-glycosylation site {N444} N-glycosylation site {N491} N-glycosylation site {N542} transmembrane domain {558-578} cytoplasmic loop {579-634} MOTIF: asparagine residue {615} transmembrane domain {635-655} exoplasmic loop {656-817} MOTIF: N-glycosylation site {N688} transmembrane domain {818-838} cytoplasmic domain {839-1484} MOTIF: Ser phosphorylation site {S917} Ser phosphorylation site {S930} Tyr phosphorylation site {Y932} Tyr phosphorylation site {Y949} Tyr phosphorylation site {Y962} histidine-rich region {984-989} MOTIF: histidine residue (SEVERAL) Tyr phosphorylation site {Y1039} Tyr phosphorylation site {Y1049} Ser phosphorylation site {S1061} Thr phosphorylation site {T1065} Tyr phosphorylation site {Y1070} Tyr phosphorylation site {Y1109} Tyr phosphorylation site {Y1155} Ser phosphorylation site {S1166} Tyr phosphorylation site {Y1252} Ser phosphorylation site {S1303} Tyr phosphorylation site {Y1304} histidine-rich region {1361-1364} MOTIF: histidine residue (SEVERAL) Tyr phosphorylation site {Y1474} PDZ recognition motif NAME: PDZ recognition motif SITE: 1482-1484 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 138252 UniProt Q13224 Pfam PF00060 Entrez Gene 2904 Kegg hsa:2904

References

  1. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al. Molecular diversity of the NMDA receptor channel. Nature. 1992 Jul 2;358(6381):36-41. PMID: 1377365
  2. Ghosh A. Neurobiology. Learning more about NMDA receptor regulation. Science. 2002 Jan 18;295(5554):449-51. No abstract available. PMID: 11799227
  3. UniProt :accession Q13224