glutamate receptor 4; GluR-4; GluR4; GluR-D; glutamate receptor ionotropic, AMPA 4; AMPA-selective glutamate receptor 4 (GRIA4 GLUR4)

Function: - ionotropic glutamate receptor - binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, & thereby converts the chemical signal to an electrical impulse - the receptor then desensitizes rapidly & enters a transient inactive state, characterized by the presence of bound agonist - palmitoylated a) depalmitoylated upon glutamate stimulation b) Cys-611 palmitoylation leads to Golgi retention & decreased cell surface expression c) in contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation- dependent endocytosis (putative) - interacts with EPB41L1 via its C-terminus (putative) - receptor binds AMPA (quisqualate) > glutamate > kainate Structure: - homotetramer or heterotetramer of pore-forming glutamate receptor subunits - tetramers may be formed by the dimerization of dimers - belongs to the glutamate-gated ion channel (TC 1.A.10) family Compartment: - cell membrane - cell junction, synapse, postsynaptic cell membrane

Properties

SIZE: entity length = 902 aa MW = 101 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {21-544} MOTIF: signal sequence {1-20} N-glycosylation site {N56} N-glycosylation site {N258} N-glycosylation site {N371} N-glycosylation site {N407} N-glycosylation site {N414} Glutamate binding {500-502} binding site SITE: 507-507 FOR-BINDING-OF: Glutamate transmembrane domain {545-565} cytoplasmic loop {566-625} MOTIF: cysteine residue {C611} MODIFICATION: palmitate COMPARTMENT: membrane transmembrane domain {626-646} exoplasmic loop {647-813} MOTIF: Glutamate binding {676-677} binding site SITE: 727-727 FOR-BINDING-OF: Glutamate transmembrane domain {814-834} cytoplasmic domain {835-902} MOTIF: cysteine residue {C837} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 138246 UniProt P48058 PFAM correlations Entrez Gene 2893

References

UniProt :accession P48058