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gremlin-2 (cysteine knot superfamily 1 BMP antagonist 2, protein related to DAN & cerberus, GREM2, CKTSF1B2, DAND3, PRDC)
Function:
1) cytokine
2) inhibits activity of BMP2 & BMP4 (dose-dependent)
3) antagonizes BMP4-induced suppression of progesterone production in granulosa cells
Compartment: secreted
Related
gremlin-1 (cysteine knot superfamily 1 BMP antagonist 1, increased in high glucose protein 2, IHG-2, down-regulated in Mos-transformed cells protein, proliferation-inducing gene 2 protein, GREM1, CKTSF1B1, DAND2, DRM, PIG2)
General
cytokine
Properties
SIZE: MW = 19 kD
entity length = 168 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
N-glycosylation site {N40}
CTCK {73-163}
MOTIF: cysteine residue {C73}
MODIFICATION: cysteine residue {C123}
cysteine residue {C87}
MODIFICATION: cysteine residue {C137}
cysteine residue {C97}
MODIFICATION: cysteine residue {C155}
cysteine residue {C101}
MODIFICATION: cysteine residue {C157}
cysteine residue {C123}
MODIFICATION: cysteine residue {C73}
cysteine residue {C137}
MODIFICATION: cysteine residue {C87}
cysteine residue {C155}
MODIFICATION: cysteine residue {C97}
cysteine residue {C157}
MODIFICATION: cysteine residue {C101}
N-glycosylation site {N161}
Database Correlations
OMIM 608832
UniProt Q9H772
Pfam PF03045
References
UniProt :accession Q9H772