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protein GREB1 (gene regulated in breast cancer 1 protein, GREB1, KIAA0575)
Function:
- primary target for estrogen receptor regulation
Structure: belongs to the GREB1 family
Compartment: membrane (putative)
Alternative splicing: named isoforms=4
Expression:
- expressed in proliferating prostatic tissue & prostate cancer
- estrogen-responsive, regulated by estrogen receptors
- regulatory region of the gene contains 3 estrogen-responsive elements
- regulated by androgens
Pathology:
- acts as a regulator of hormone-dependent cancer growth in breast & prostate cancers
General
membrane protein
Properties
SIZE: entity length = 1949 aa
MW = 216 kD
COMPARTMENT: cellular membrane
MOTIF: serine-rich region {1109-1232}
MOTIF: serine residue (SEVERAL)
transmembrane domain {1868-1888}
Database Correlations
UniProt Q4ZG55
Kegg hsa:9687
References
UniProt :accession Q4ZG55