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gramicidin/neomycin/polymixin-B (Opthneosporin, AK-spore)
A combination of gramicidin + neomycin + polymixin-B.
Indications:
- treatment of ocular bacterial infections due to S. aureus, S. pneumoniae, Neisseria, E. coli, H. influenzae, K. pneumoniae, K. aerogenes, Proteus
Dosage:
- 1-2 drop 4-6 times daily Solution (ophthalmic) neomycin sulfate: 1.75 mg polymixin B sulfate 10,000 units gramicidin 0.025 mg/mL (10 mL)
Adverse effects:
- not common (1-10%)
- edema, itching, reddening, failure to heal, low-grade conjunctivitis
Mechanism of action:
1) inhibits bacterial protein synthesis
2) alters bacterial cell wall permeability
General
antibiotic combination
References
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998 - not on National VA formulary
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Components
gramicidin
neomycin (Mycifradin)
polymixin B (Aerosporin)