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graft-versus-leukemia (GVL)
effect mediated via donor T cells & natural killer cells effective in eliminating residual host acute myeloid leukemia (AML) cells after allogeneic stem-cell transplantation
Pathology:
- relapses of leukemia may occur when residual host leukemia cells lose human leukocyte antigen (HLA) surface antigens recognized by donor T cells & natural killer cells & express only the haplotype inherited from one parent (uniparental disomy), the matched donor haplotype, thus eliminating donor effector-cell immunoreactivity [1]
General
graft versus host disease (GVHD)
References
- Vago L et al
Loss of mismatched HLA in leukemia after stem-cell
transplantation.
N Engl J Med 2009 Jul 30; 361:478
PMID: 19641204
- Barrett J and Blazar BR.
Genetic trickery - Escape of leukemia from immune attack.
N Engl J Med 2009 Jul 30; 361:524.
PMID: 19641211