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Global Registry of Acute Coronary Events (GRACE) study

,Global Registry of Acute Coronary Events (GRACE) Study characteristics: - Cohort study - 94 hospitals in 14 countries - 19,537 patients presenting with acute coronary syndrome - April 1999 to September 2002 Groups: - Statin use before presentation (1a) - Statin use discontinued upon hospital admission (1b) - Statin started after presentation (2) - No statin use (3) End points: - death, in-hospital myocardial infarction, & stroke Results: 1) patients in group 1 were less likely to have a) ST-segment elevation (odds ratio 0.79) b) myocardial infarction (OR 0.78) 2) patients in group 1a were less likely to experience complications or die than patients in group 3 (OR 0.66) 3) patients in group 2 were less likely to die than patients in group 3 (OR 0.38) 4) adjustment for the hospital of admission attenuated the association between initiation of statin therapy & the composite end point (OR 0.84)

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clinical trial

References

  1. Journal Watch 24(14):110, 2004
    1. Spencer FA, Allegrone J, Goldberg RJ, Gore JM, Fox KA, Granger CB, Mehta RH, Brieger D; GRACE Investigators. Association of statin therapy with outcomes of acute coronary syndromes: the GRACE study. Ann Intern Med. 2004 Jun 1;140(11):857-66. PMID: 15172899
    2. Laupacis A, Mamdani M. (editorial) Observational studies of treatment effectiveness: some cautions. Ann Intern Med. 2004 Jun 1;140(11):923-4. No abstract available. PMID: 15172907