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guanine nucleotide-binding protein Gq subunit alpha (guanine nucleotide-binding protein alpha-q, GNAQ, GAQ)
Function:
- activates PLC beta-1
- binds SLC9A3R1
Structure: belongs to the Gq-alpha family
Expression:
- predominantly expressed in ovary, prostate, testis & colon
General
Gq-alpha family (GNAQ)
Properties
SIZE: entity length = 353 aa
MW = 41 kD
COMPARTMENT: plasma membrane*
CELL: most cell types*
ORGANISM: eukaryote*
MOTIF: cysteine residue {C3}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C4}
MODIFICATION: palmitate
COMPARTMENT: membrane
GTP-binding site
SITE: 40-47
GTP-binding site
SITE: 199-203
GTP-binding site
SITE: 268-271
Database Correlations
OMIM 600998
UniProt P50148
Pfam PF00503
References
- Taylor et al,
Activation of the beta 1 isozyme of phospholipase C by alpha
subunits of the Gq class of G proteins.
Nature 350:516 1991
PMID: 1707501
- UniProt :accession P50148
Component-of
Gq-protein