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G-protein coupled receptor-associated sorting protein 1; GASP-1 (GPRASP1, GASP, KIAA0443)
Function:
1) lysosomal sorting & down-regulation of G-protein coupled receptors
2) targets G-protein coupled receptors for degradation in lysosomes
3) interacts with cytoplasmic tails of G-protein coupled receptors:
a) dopamine D2 receptor
b) dopamine D4 receptor
c) delta opioid receptor
d) beta-2 adrenergic receptor
4) interacts with PER1
Structure: belongs to the GPRASP family
Compartment: cytoplasm
Expression:
- expressed in brain > medulla, spinal cord, substantia nigra
General
other protein
Properties
SIZE: MW = 157 kD
entity length = 1395 aa
MOTIF: glutamate-rich region {506-978}
MOTIF: glutamate residue (SEVERAL)
binding site
SITE: 899-1395
FOR-BINDING-OF: delta opioid receptor
Database Correlations
OMIM 300417
UniProt Q5JY77
Pfam PF04826
Entrez Gene 9737
Kegg hsa:9737
References
UniProt :accession Q5JY77