Search
gonadotropin-releasing hormone/factor; gonadoliberin; LH/FSH-releasing hormone (GnRH, LHRH)
Function:
- stimulates LH & FSH secretion from the anterior pituitary
- pulsatile secretion is essential for activity of GnRH
- increased frequency of GnRH pulses occurs during the early follicular phase of the menstrual cycle
- binds with high affinity to LH receptors & FSH receptors on pituitary gonadotrophs resulting in activation of phospholipase C
- suggested to have anti-aging and anti-inflammatory properties [3]
Structure:
- decapeptide
Compartment:
- secreted
Expression:
- secreted in a pulsatile fashion from the hypothalamus
Pharmacology:
- continuous stimulation with long-acting GnRH agonists (goserelin, gonadorelin) effectively castrates men with prostate cancer
Pharmacokinetics:
- its half-life (2-4 min) is short
Related
follicle-stimulating hormone; follitropin (FSH)
gonadotropin-releasing hormone [GNRH] receptor
hypothalamus
LHRH deficiency (gonadotropin-releasing hormone deficiency)
luteinizing hormone; lutropin (LH)
menotropins (Pergonal, Repronex)
Specific
gonadotropin-releasing hormone/factor 1; gonadoliberin 1; LH/FSH-releasing hormone 1; gonadorelin (GnRH1, LHRH-1)
gonadotropin-releasing hormone/factor; gonadoliberin 2; LH/FSH-releasing hormone 2 (GnRH2, LHRH2)
General
pituitary hormone-releasing hormone; hypothalamic hormone
Properties
COMPARTMENT: extracellular compartment
MOTIF: amide
SITE: C-TERMINUS
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Popat V and Cowan BD
Gonadotropin-Releasing Hormone Deficiency in Adults
http://emedicine.medscape.com/article/255152-overview
- Zhang G, Li J, Purkayastha S, Tang Y
Hypothalamic programming of systemic ageing involving IKK-beta,
NF-kappaB and GnRH.
Nature. 2013 May 1
PMID: 23636330
- Gabuzda D and Yankner BA.
Physiology: Inflammation links ageing to the brain.
Nature 2013 May 9; 497:197.
PMID: 23636321