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gonadotropin-releasing hormone/factor 1; gonadoliberin 1; LH/FSH-releasing hormone 1; gonadorelin (GnRH1, LHRH-1)
Function:
- stimulates secretion of gonadotropins
- it stimulates secretion of both LH & FSH
Structure:
- decapeptide
- belongs to the GnRH family
Compartment:
- GnRH1 is completely confined to the hypophyseal-portal blood supply
Expression:
- secreted in a pulsatile fashion from the hypothalamus
Pharmacology: see Lutrepulse (Relisorm, Factrel)
Related
follicle-stimulating hormone; follitropin (FSH)
gonadotropin-releasing hormone [GNRH] receptor
hypothalamus
luteinizing hormone; lutropin (LH)
menotropins (Pergonal, Repronex)
General
gonadotropin-releasing hormone/factor; gonadoliberin; LH/FSH-releasing hormone (GnRH, LHRH)
Properties
SIZE: MW = 10 kD
entity length = 92 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
amide
SITE: C-TERMINUS
Database Correlations
OMIM 152760
UniProt P01148
Pfam PF00446
Entrez Gene 2796
Kegg hsa:2796
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Uniprot :accession P01148