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Golgin subfamily B member 1; 372 kD Golgi complex-associated protein; GCP372; Giantin; macrogolgin (GOLGB1)
Function:
- may participate in forming intercisternal cross-bridges of the Golgi complex
- interacts with PLK3
Structure:
- homodimer; disulfide-linked
Compartment:
- Golgi membrane; single-pass type 1 membrane protein
Pathology:
- autoantigen in chronic rheumatoid arthritis & in Sjogren's syndrome
General
Golgin subfamily B (GOLGB)
phosphoprotein
Properties
SIZE: entity length = 3259 aa
MW = 376 kD
COMPARTMENT: golgi
MOTIF: Ser phosphorylation site {S6}
Ser phosphorylation site {S17}
Ser phosphorylation site {S38}
Thr phosphorylation site {T45}
Thr phosphorylation site {T46}
coiled coil {48-593}
coiled coil {677-1028}
MOTIF: Ser phosphorylation site {S967}
coiled coil {1062-1245}
coiled coil {1301-1779}
coiled coil {1828-3185}
MOTIF: glutamate-rich region {2420-2423}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S2872}
serine-rich region {2993-2996}
MOTIF: serine residue (SEVERAL)
transmembrane domain {3236-3256}
Database Correlations
OMIM 602500
UniProt Q14789
Entrez Gene 2804
Kegg hsa:2804
References
UniProt :accession Q14789