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Golgin subfamily A member 4; 256 kD golgin; Golgin-245; protein 72.1; trans-Golgi p230 (GOLGA4)
Function:
- may play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1
- interacts with ARL1 with bound GTP
- interacts with MACF1
Structure:
- homodimer
- extended rod-like protein with coiled-coil domains
- contains 1 GRIP domain
Compartment:
- cytoplasm
- Golgi membrane
Alternative splicing:
- named isoforms=3
- additional isoforms seem to exist
Pathology:
- antibodies against GOLGA4 are found in sera from patients with Sjogren's syndrome & hepatitis B
Related
hepatitis B infection
Sjogren's syndrome (autoimmune epitheliitis)
General
Golgin subfamily A (GOLGA)
phosphoprotein
Properties
SIZE: entity length = 2230 aa
MW = 261 kD
COMPARTMENT: cytoplasm
golgi
MOTIF: Ser phosphorylation site {S40}
Ser phosphorylation site {S41}
Ser phosphorylation site {S71}
Ser phosphorylation site {S89}
coiled coil {133-2185}
MOTIF: MACF1 interaction {133-203}
glutamate-rich region {252-2096}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S266}
Thr phosphorylation site {T342}
Thr phosphorylation site {T346}
GRIP {2168-2215}
Thr phosphorylation site {T2223}
Database Correlations
OMIM 602509
UniProt Q13439
Pfam PF01465
Entrez Gene 2803
Kegg hsa:2803
References
UniProt :accession Q13439