Golgin subfamily A member 2; 130 kD cis-Golgi matrix protein; GM130; GM130 autoantigen; Golgin-95 (GOLGA2)

Function: - probably involved in maintaining cis-Golgi structure - part of a larger oligomeric complex - interacts with p115 (putative) - interacts with RAB1B that has been activated by GTP-binding - interacts with GORASP1/GRASP65 & ZFPL1 Structure: - extended rod-like protein with coiled-coil domains - belongs to the GOLGA2 family Compartment: - Golgi, Golgi stack membrane Alternative splicing: named isoforms=2 Pathology: - Golgi auto-antigen

General

Golgin subfamily A (GOLGA) phosphoprotein

Properties

SIZE: entity length = 1002 aa MW = 113 kD COMPARTMENT: golgi MOTIF: coiled coil {16-892} MOTIF: Ser phosphorylation site {S20} Ser phosphorylation site {S37} lysine-rich region {46-51} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S123} Ser phosphorylation site {S438} proline-rich region SITE: 449-455 MOTIF: proline residue (SEVERAL) glutamate-rich region {704-715} MOTIF: glutamate residue (SEVERAL)

Database Correlations

OMIM 602580 UniProt Q08379 Entrez Gene 2801 Kegg hsa:2801

References

UniProt :accession Q08379