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guanine nucleotide binding protein (G protein), gamma 7; GTP-binding regulatory protein gamma-7 (GNG7, GNGT7)
Function:
- G-gamma, component of G-beta-gamma
- G-beta & G-gamma chains are required for
a) GTPase activity of heterotrimeric G proteins
b) replacement of GDP by GTP
c) G protein-effector interaction
Structure: belongs to the G protein gamma family
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side (putative)
Expression: expressed in a variety of tissues
Pathology:
- down-regulated in pancreatic cancer
Related
G-beta/gamma
G-protein
General
guanine nucleotide binding protein (G protein), gamma subunit
Properties
SIZE: entity length = 68 aa
MW = 8 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 604430
UniProt O60262
Pfam PF00631
Entrez Gene 2788
Kegg hsa:2788
References
UniProt :accession O60262