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GTP-binding regulatory protein beta-3; transducin beta chain 3 (GNB3)
Function:
- G-beta & G-gamma chains are required for
a) GTPase activity of heterotrimeric G proteins
b) replacement of GDP by GTP
c) G protein-effector interaction
Structure:
- G proteins are composed of 3 units G-alpha, G-beta & G-gamma
- belongs to the WD repeat G protein beta family
- contains 7 WD repeats
Expression: nearly ubiquitously expressed
Polymorphism:
- a single-nucleotide polymorphism, rs1047776 in GNB3, seems to accelerate cognitive impairment in men receiving androgen deprivation therapy [4]
Related
G-beta/gamma
G-protein
General
GTP-binding regulatory protein beta
phosphoprotein
Properties
SIZE: entity length = 340 aa
MW = 37 kD
MOTIF: WD repeat {53-83}
MOTIF: Ser phosphorylation site {S74}
WD repeat {95-125}
WD repeat {141-170}
WD repeat {182-212}
WD repeat {224-254}
WD repeat {268-298}
WD repeat {310-340}
Database Correlations
OMIM 139130
UniProt P16520
Entrez Gene 2784
Kegg hsa:2784
References
- Simon MI, Strathmann MP, Gautam N.
Diversity of G proteins in signal transduction.
Science. 1991 May 10;252(5007):802-8. Review.
PMID: 1902986
- Hepler JR & Gilman AG
G proteins
TIBS 17:383 1992
PMID: 1455506
- UniProt :accession P16520
- Castellino AM
Cognitive Impairment Linked to Androgen Deprivation Therapy.
Medscape Oncology. May 14, 2015
http://www.medscape.com/viewarticle/844690
- Gonzalez BD et al
Course and Predictors of Cognitive Function in Patients With
Prostate Cancer Receiving Androgen-Deprivation Therapy:
A Controlled Comparison.
American Society of Clinical Oncology. May 11, 2015