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GTP-binding regulatory protein Gi alpha-2 (guanine nucleotide binding protein Gi alpha-2, heterotrimeric G-protein Gi alpha-2, GNAI2)
Function:
- Gi-alpha subunit of Gi proteins
- inhibition of adenylate cyclase in response to beta-adrenergic stimuli
- interacts with GPSM1 (putative)
- interacts with UNC5B
Structure: belongs to the Gi-alpha family
Alternative splicing: named isoforms=2
Related
Gi-protein
General
Gi-alpha
Properties
SIZE: entity length = 355 aa
MW = 40 kD
COMPARTMENT: plasma membrane*
CELL: most cell types*
ORGANISM: eukaryote*
MOTIF: myristoylation site
SITE: G2
EFFECTOR-BOUND: myristate
cysteine residue {C3}
MODIFICATION: palmitate
COMPARTMENT: membrane
GTP-binding site
SITE: 40-47
GTP-binding site
SITE: 201-205
GTP-binding site
SITE: 270-273
Database Correlations
OMIM 139360
UniProt P04899
References
- Bourne HR et al,
The GTPase superfamily: a conserved switch for diverse cell
functions
Nature 348:125 1990
PMID: 2122258
- Hepler JR & Gilman AG
G proteins
TIBS 17:383 1992
PMID: 1455506
- UniProt :accession P04899