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granulocyte-macrophage colony-stimulating factor; GM-CSF; colony-stimulating factor 2; molgramostin; sargramostim (CSF2, GMCSF)
Function:
- cytokine that stimulates growth & differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils & erythrocytes
- activation of endothelial cells
Structure:
- monomer
- belongs to the GM-CSF family
Compartment: secreted
Polymorphism:
- variant Ile-117 may be a risk factor for atopic asthma
Pharmacology:
- available as sargramostim (Leukine, Leucomax)
Specific
Granulocyte Macrophage Csf Parenteral
sargramostim [GM-CSF] (Leukine, Prokine, Leucomax)
General
colony-stimulating factor (CSF)
glycoprotein
Properties
SIZE: entity length = 144 aa
MW = 16 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
Ser glycosylation site {S22}
Ser glycosylation site {S24}
Ser glycosylation site {S26}
Thr glycosylation site {T27}
N-glycosylation site {N44}
N-glycosylation site {N54}
cysteine residue {C71}
MODIFICATION: cysteine residue {C113}
cysteine residue {C105}
MODIFICATION: cysteine residue {C138}
cysteine residue {C113}
MODIFICATION: cysteine residue {C71}
cysteine residue {C138}
MODIFICATION: cysteine residue {C105}
SECRETED-BY: fibroblast
macrophage
endothelial cell
T-cell
MISC-INFO: 1/2life 1 HOUR
Database Correlations
OMIM 138960
UniProt P04141
Pfam PF01109
Entrez Gene 1437
Kegg hsa:1437
References
- UniProt :accession P04141
- Leukine; Note: Clinical information on Leukine
http://www.leukine.com/hcp/index.html
- SeattleSNPs
http://pga.gs.washington.edu/data/csf2/
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 679