GM1 ganglioside; monosialoganglioside

Gal-(B1,3)-GalNAc-(B1,4)-Gal-(B1,4)-Glc-Ceramide | (a2,3)-NANA Oligomers or polymers (fibrils) of A4/42 in lipoprotein complexes associated with GM1 may be the initial precipitating species in neuritic plaques of Alzheimer's disease. Laboratory: - ganglioside GM1 Ab in serum - ganglioside GM1 IgG in serum - ganglioside GM1 IgM in serum - ganglioside GM1 IgG in CSF - ganglioside GM1 IgM in CSF

Related

A4 amyloid peptide; beta-peptide GM1 gangliosidosis

Properties

COMPARTMENT: plasma membrane

References

- Michikawa M, Gong JS, Fan QW, Sawamura N, Yanagisawa K. A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release. J Neurosci. 2001 Sep 15;21(18):7226-35. PMID: 11549733