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lactoylglutathione lyase; methylglyoxalase; aldoketomutase; glyoxalase I; Glx I; ketone-aldehyde mutase; S-D-lactoylglutathione methylglyoxal lyase (GLO1)
Function:
- catalyzes conversion of hemimercaptal, formed from methylglyoxal & glutathione, to S-lactoylglutathione
- secondary metabolite metabolism; methylglyoxal degradation; D-lactate from methylglyoxal: step 1/2
Cofactor: binds 1 Zn+2 per subunit
Structure:
- homodimer
- belongs to the glyoxalase I family
Polymorphism:
- 3 separable isoforms which originate from 2 alleles in the genome
- these correspond to two homodimers & one heterodimer composed of two subunits showing different electrophoretic properties
Related
hydroxyacylglutathione hydrolase, mitochondrial; glyoxalase II; Glx II (HAGH, GLO2, HAGH1)
General
lyase
Properties
SIZE: entity length = 184 aa
MW = 21 kD
MOTIF: Zn+2-binding site
SITE: 34-34
active site
Zn+2-binding site
SITE: 100-100
Zn+2-binding site
SITE: 127-127
Zn+2-binding site
SITE: 173-173
Database Correlations
OMIM 138750
UniProt Q04760
Pfam PF00903
Entrez Gene 2739
Kegg hsa:2739
ENZYME 4.4.1.5
References
UniProt :accession Q04760