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peptide N-myristoyltransferase (myristoyl-CoA:protein N-myristoyltransferase, NMT, NMT1, glycylpeptide N-tetradecanoyltransferase)
Function:
- N-myristoyl transferase is active cotranslationally on polyribosomes
- myristoylation of N-terminal glycine residues is generally constitutive resulting in a stably modified protein that associates with cellular membranes [2]
Structure: belongs to the NMT family
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression: expressed in heart, gut, kidney, liver, placenta
Related
glycylpeptide N-tetradecanoyltransferase 2; Myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; peptide N-myristoyltransferase 2; type II N-myristoyltransferase (NMT2)
myristoylation
myristoylation site
General
acyltransferase
Properties
SIZE: entity length = 496 aa
MW = 57 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S31}
Ser phosphorylation site {S47}
lysine-rich region {55-67}
MOTIF: lysine residue (SEVERAL)
Database Correlations
OMIM 160993
UniProt P30419
PFAM correlations
Kegg hsa:4836
ENZYME 2.3.1.97
References
- Sefton & Buss J Cell Biol 104:1449 1987
- Casey PJ
Protein lipidation in cell signaling.
Science 268:221 1995
PMID: 7716512