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Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; plasmodium vivax receptor; CD234 (DARC, FY, GPD)

Function: non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 & TARC. It is also the receptor for the human malaria parasites plasmodium vivax & plasmodium knowlesi Structure: belongs to the G-protein coupled receptor Duffy family Compartment: membrane Alternative splicing: named isoforms=2 Expression: - found in adult kidney, adult spleen, bone marrow & fetal liver - expressed along postcapillary venules throughout the body, except in the adult liver - erythroid cells & postcapillary venule endothelium are principle tissues expressing duffy - Fy(-A-B) individuals do not express duffy in the bone marrow; however, they do, in postcapillary venule endothelium Polymorphism: - DARC is responsible for the Duffy blood group system - the molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) & Asp-42 to Fy(B) - genetic variation in DARC is associated with white blood cell count quantitative trait locus type 1 (WBCQ1) Pathology: - individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to vivax malaria - this allele is found predominantly in population of African origin

Related

Duffy blood group locus

General

blood group antigen cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 336 aa MW = 36 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-63} MOTIF: N-glycosylation site {N16} N-glycosylation site {N33} cysteine residue {C51} MODIFICATION: cysteine residue {C276} transmembrane domain {64-84} cytoplasmic loop {85-95} transmembrane domain {96-116} exoplasmic loop {117-129} MOTIF: cysteine residue {C129} MODIFICATION: cysteine residue {C195} transmembrane domain {130-153} cytoplasmic loop {154-166} transmembrane domain {167-187} exoplasmic loop {188-207} MOTIF: cysteine residue {C195} MODIFICATION: cysteine residue {C129} transmembrane domain {208-228} cytoplasmic loop {229-244} transmembrane domain {245-265} exoplasmic loop {266-287} MOTIF: cysteine residue {C276} MODIFICATION: cysteine residue {C51} transmembrane domain {288-308} cytoplasmic domain {309-336}

Database Correlations

OMIM correlations UniProt Q16570 Kegg hsa:2532

References

  1. UniProt :accession Q16570
  2. BGMUT; Blood group antigen gene mutation database http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=duffy
  3. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=DARC
  4. Wikipedia; Note: Duffy antigen entry http://en.wikipedia.org/wiki/Duffy_antigen