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non-enzymatic glycosylation (Maillard reaction)
Chronic hyperglycemia may result in non-enzymatic glycation of proteins with accumulation of AGE pigments. These AGE pigments may accumulate in extracellular proteins with slow turnover, i.e collagen. Hemoglobin A1c is probably the best known example of non-enzymatic glycation.
Related
advanced glycation endproduct (AGE) pigment
General
catabolic pathway
References
- Principles of Geriatric Medicine & Gerontology, 4th edition,
Hazzard WR et al, eds, McGraw Hill, New York, 1999, pg 999
- Wikipedia: Maillard reaction
https://en.wikipedia.org/wiki/Maillard_reaction