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glutathione peroxidase-1 (GSH-Px1, cellular glutathione peroxidase, GPX1)
Function:
- protects hemoglobin in erythrocytes from oxidative breakdown
2 glutathione + H2O2 glutathione disulfide + 2 H2O
Structure:
- homotetramer
- belongs to the glutathione peroxidase family
Compartment: cytoplasm
Expression:
- highly expressed in auditory hair cells
Pathology:
- higher blood levels associated with lower rates of cardiovascular events in patients with suspected coronary artery disease [2], relative risk 0.29 from highest vs lowest quartiles
Pharmacology:
- ebselen mimics activity of GPx1 & may prevent noise-induced hearing loss
General
glutathione peroxidase
Properties
SIZE: entity length = 201 aa
MW = 22 kD
COMPARTMENT: cytoplasm
MOTIF: cysteine residue {C47}
selenocysteine residue {C47}
Database Correlations
OMIM 138320
UniProt P07203
Pfam PF00255
Entrez Gene 2876
KEGG correlations
ENZYME 1.11.1.9
References
- UniProt :accession P07203
- Journal Watch 23(24):191, 2003
Blankenberg S, N Engl J Med 349:1605, 2003
pmid: 14573732
- UniProt :accession P07203
- Wikipedia, Glutathione peroxidase entry
http://en.wikipedia.org/wiki/Glutathione_peroxidase
- Kil J, Lobarinas E, Spankovich C et al
Safety and efficacy of ebselen for the prevention of noise-
induced hearing loss: a randomised, double-blind, placebo-
controlled, phase 2 trial.
Lancet. July 14, 2017
PMID: 28716314
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31791-9/fulltext
- Maison SF, Rauch SD
Ethical considerations in noise-induced hearing loss research.
Lancet. July 14, 2017
PMID: 28716312
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31875-5/fulltext